Seven Hours to Adequate Antimicrobial Therapy in Urosepsis Using Isothermal Microcalorimetry
نویسندگان
چکیده
منابع مشابه
Seven hours to adequate antimicrobial therapy in urosepsis using isothermal microcalorimetry.
Urosepsis can progress toward severe sepsis, septic shock, and, ultimately, death. Rapid antimicrobial susceptibility testing is crucial to decrease mortality and morbidity. This report shows that isothermal microcalorimetry can provide an antibiogram within 7 h with a sensitivity of 95% and specificity of 91% using Vitek-2 system as a reference.
متن کاملSeven hours to adequate antimicrobial therapy in urosepsis
31 32 Urosepsis can progress toward severe sepsis, septic shock and ultimately death. Rapid 33 antimicrobial susceptibility testing is crucial to decrease mortality and morbidity. This 34 study shows that isothermal microcalorimetry can provide an antibiogram within 7 hours 35 with a sensitivity of 95% and specifity of 91% when using VITEK-2® system as 36 reference. 37 38 39 Main text: 40 41 Ur...
متن کاملStandards in Isothermal Microcalorimetry
The main calorimetric principles used in isothermal microcalorimetry are briefly discussed. Different chemical calibration and test reactions are discussed, with a focus on reactions suitable for ambient conditions: reactions initiated by mixing of liquids (including titration microcalorimetry), dissolution of solid compounds and of slightly soluble gases, a photochemical process, and thermal p...
متن کاملIsothermal microcalorimetry in applied biology
Techniques of isothermal microcalorimetry have been much improved during the past two decades. In addition to their use in fundamental research, applications of practical importance have been established in some areas. However, no significant use of isothermal microcalorimetry has yet been seen in practical applications of biology, despite many methodological studies reported from that area. Th...
متن کاملIsothermal Microcalorimetry to Investigate Non Specific Interactions in Biophysical Chemistry
Isothermal titration microcalorimetry (ITC) is mostly used to investigate the thermodynamics of "specific" host-guest interactions in biology as well as in supramolecular chemistry. The aim of this review is to demonstrate that ITC can also provide useful information about non-specific interactions, like electrostatic or hydrophobic interactions. More attention will be given in the use of ITC t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2013
ISSN: 0095-1137
DOI: 10.1128/jcm.02374-13